Document zozEa1nLkO9x6YjGopyq7QqD6

MINUTES or THE KEE7IKC AT KTTIIKC LABORATORY *....................... - June 22. ' P r e t e s e : Dr JLy=ond R. S u s k in d , K e t t e r i n g Dr J u l t n Fcnn, Dr R. C. V t l l e e e , M onsanto, H itro Mr C. F . L u e c k e , M onsanto, N i t r o Mr K. L . G o d frey , .H o a to to , K icro Mr E. P . V h e e le r, H o n te n to , S t. Louis Mr P. K. B e v ie s , E la g g , S to n e , Maury, A nderson, end Bowles L. C. Veger, Monsanto, Kicro 1 Dr. S u sk in d .pre ser.ted tbe (roup v itb copies of a w ritten ru = a ry o f tb e e x p e rim e n ta l work done e t th e K e tte rin g L aboratory during the p e s t se v e ra l m onths. A copy o f th is si= sery I t a tta c h e d . D r. S u sk in d e l a b o r a t e d cro tb e work c o v e re d by tb e r e p o r t end by sk etch in g * c ra s s -s e c tio n o f the sk in explained to th e group hov c h lo r-a c n e a f f e c ts the b a ir f o l l i c l e and the sebaceous gland. Dr. Suskind p o in ted out th a t tbe p ercen t concentration,.and to ta l dose r e f e r r e d to in th e ta b le in h is stnxaary re p re s e n ts the s ta p le in each case and n o t a c tu a l tric h lo ra p h e n a te . I t vas not p o ssib le t o u s e h i g h e r c o n c e n t r a t io n s o f Sodium TCP b e c a u s e o f th e extrem e i r r i t a t i o n o f th e sk in so th a t w hile tbe Halovax vas applied as a 2Cl c o n c e n t r a t i o n t b e mx.1m.ra c o n c e n t r a t io n o f any o f th e TCP * = p lc t v a s 71 acid i n sone i n s t a n c e s v a s h e ld a s low a s 2 .5 1 o r 2.51 and 0.751 tr-ichloropbeool. E v e n ..ii.^ v ^ c ^ .th e ..d if f tr e n c s s In co n cen t r a t io n , Dr.. Suskind a (found o u r.'n o rm al" S o d iu a T r ic h lo r o p h e n a tt p ro d u c in g de f in i t if .c h lo r-a c n e . ' The Sodiua T ric h lo ro p h e n a tt p rep ared iro n d i s t i ll e d tric h lo ro p h e n o l gave by cosparlson a d i d re a c tio n and v lth the ex cep tio n o f one s lid e seen iro n one o f the fo u r su b jects used, th e re v as no ev id en ce o f a c tu a l c h lo r-a c n e . The re a c tio n to the m a te r ia l p re p a re d by th e Diamond A lk a li p u r i f i c a t i o n p ro cess (d ilu tio n , f i l t r a t i o n , and p re c ip ita tio n ) vas le ss narked than tbe sample p rep ared by d i s t i l l a t i o n . Dr. Suskind in d ic a te d th a t fu tu re work a t K e tte rin g e ig h t extend along t i d i e r lin e s to fu rth e r c lt r if y w hether p u rifie d m aterials w ere a c t u a l l y n o n -e c n e g e n le o r t h a t wnrk e i g h t be u n d e rta k e n to *  C-TV. T *--f " r~ "` --.~--~~*~Tt-*.>> SSSiFi ' % .* y-Trr-^" c t : f -- : n c s u c h c : h t : i r. f c -- at ior. <s would be c ! i r . z e r t r . ;o .`or.samco. Dr. Suik^nc w i l l be cr. v a c a t i o n t h r oug h the month o f J u l y to t h a t no f u r t h e r work c o u l d be i n i t i a t e d b e f o r e acme time in August. /7T h r . El mer V h e e l e r d i s c u s s e d h i r e c e n t v i s i t w i t h BASF In ^ C-er~r_a- y . He d a t e d t h a t e s s e n t i a l l y a l l t h e p e r t i n e n t i n f o r m a t i o n i s c o n t a i n e d i n h i t a e o o r a r d a and c mTb a s i i e d t h a0t t h e 1I pe-ople a t BASF were v e r y c u t i o u i t o e x c h an ge i n f o r m a t i o n with K m s an t o and T-t 11 e r i n g on a l l p h a s e s o f the p r o b l e m . Re v a i ^ g i v e n the i m p r e s s i o n a t the tl_ o f h i s v i s i t t h a t th e y r e 1 prepared to exchange a ll information including process d atak bu t t h a t i t was no t p o s s i b l e a t the o e e t i n g s i n c e ha did notj have Monsanto p rocess in formaticm w ith him. It appeared to ^ Mr. V b e e l e r Chat Che symptoms and c o m p l a i n t s m a n i f e s t e d by t h e w o r k e r s i n t h e Get-can p l a n t p a r a l l e l e d t h e Monsanto e x - f p e r i e-nce, b u t i t wea h i i crpi n i o n t h a t t& t German c a a e a w e re p r o b a b l y more s e v e r e . Dr. O e t t e l o f BASF s t t o e d p a r t i c u l a r l y * I n t e r e s t e d t h a t the Monsanto ca e c a bad a l s o p r e s e n t e d o b j e c t i v e complaints suggesting peripheral neuritis. I t was a greed t h a t Mr. V b e e l e r w i l l r e q u e s t ap p r o v a l f r o t h e O r g a n i c D i v i s i o n f o r e x c h a n g e o f i n f o r m a t i o n w i t h BASF, and i t i s a n t ic ip a t e d that Dr. Suakiod w i l l correspond d ir e c t l y w ith D r . O e t t e l . and t h a t someone a t R it r o w i l l be d e s i g n a t e d t o c a r r y out the exchange o f ruch p la n t inform ation as i s approved. E-ach p a r t y c o n d u c t i n g c o r r e s p o n d e n c e w i l l p r o v i d e t h e o t h e r p a r t y and t h e Mems an to M e d i c a l D e p a r t m e n t w i t h c a r b o n c o p i e e __ o f a l l m a t e r i a l s s e n t and r e c e i v e d . I l l Mr. Taul S o v l e s d i s c u s s e d c e r t a i n a s p e c t s o f t h e c h l o r - a c p jt, c l a i m s Vov in l i t i g a t i o n and review ed fo r Dr. S u s k i n d s b e n e f i t acne o f the m edical^asp ects which hive been a lle g e d by t h e p h y s i c i a n f o r t he c l a i m a n t s . The p o s s i b i l i t y o f Dr. S u s k in d a p p e a r i n g aa an e x p e r t w i t n e s s was d i s c u s s e d and i t was a p p a r e n t t h a t Dr. Suskind f e e l s t h a t t h e r e was minim al e v i d e n c e o f l i v e r d i s o r d e r s and in one c a s e , e v i d e n c e o f o i r v i damage i n p e o p le e x a m i n e d i n 1 9 ^ 9 . He s t a t e d t h a t t h e r e was d o s i g n o f s u c h d i s ord ers in any o f 35 peoplt which the K etcerin g Croup examined _ at Kitro in 1953. Dr. Suskind s t r o n g ly urged th a t c o n s i d e r a t i o n be g i v e n t o p u b l i c a t i o n >* t M --rhe e xp e r i a e n t a l r e s u l t s .S32S065 ... . : "VI1_l ^ Tg f* T * - 5- >STAiA}j> jflfapfeseee t o i : t so t h a t I t c o u l d be us e d mo s t e f f e c t i v e l y ir. .f d e f e n d i n g ho r. n r . t o *s p o s i t i o n . J t v e t p o i n t e r o u t t h a t n e n t c : A t t i e group p retend was in a p o s i t i o : . to give ap p ro v al for p u b lic a tio n but that the b a t t e r would be considered. IT itr . L arry S h a ffe r, In d u s tria l H ygienist a t K etterin g Laboratory, was i n v i t e d t e th e n ee t in g to c l a r i f y some cue* t io n * concerning a n a ly s i s c f a i r sam p lin g done a t K itro ir. F e b ru a ry , 1956. He s ta te d th a t vapor sam ples were re p o rte d as p a rts p e r c il li o n of c rg c r.it c h lo rid e and ch at where d u st t c r l e i were tak en they were r e p o r te d a* Hg/M s o l i d s and in c a s e s where f ig u r e s were g iv e s In itg/h of 2 ,1 ,5 -T th a t th is bad bees derived by burning a sc=ple of the so lid m aterial c o lle c te d , determ ining the ch lo rid e content end c a l c u l a t i n g back to .2 , ,5 * 7 . He s t a t e d t h a t he f e l t th e survey vas q u ite a ccu rate and re fle c te d o p eratin g conditions w ith the p o ssib le exception of the tvo s c p le s 'tax e s a t the rotoclone where v a ria n ce lx o p e ra tio n n ig h t throw th e aa sp ic abnorm ally high or lo v . _ -- .V I t v a i a g re e d t h a t th e q u e s tio n o f s u b s i t t i n g sam ples to BASF fo r e x p e rim e n ta l work would depend upon th e outcome o f th e i n i t i a l correspeodernee. , E v a lu atio n o f th e work re p o rte d b j D r. Suskind f o r p o s s ib le p ro cess and e n g in e e rin g work w ill be done by th e group a t H !tr .# Tie q u estio n of fu tu re vork a t tb e K etterin g L aboratory w ill be considered along w ith tbe p o s s ib llitT o f experim ental vork at BASF. LCV/ f j 6-26*56 L. C. V eger HZJL'SOKG si#