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ARag6_ 343 | { | { 418 i | | || [5rarGov-- age Sty-- n Ra ih OneGerm Reprodstion Evations HAAG - 3236 RDeuvriosendsP3a8g6e "TRADE SECRET Study Title H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats `with One-Generation Reproduction Evaluations Revision No. 1 Volume 3 of 5 "TEST GUIDELINES: U.S. EPA Health Effects Test Guidelines (OPPTS 870.3100 (1998) AUTHOR: Gregory S. Ladics, Ph.D., D.AB.T. ORIGINAL COMPLETED ON: December 3, 2001 REVISION NO. 1 COMPLETED ON: April 5, 2002 PERFORMING LABORATORY: E.I du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Won Reaves NoseDsY Seavics Cone Novae:(8} srorson srupy Nove: [SEED| Company Sanlizad. Does not containTSCACBI -- mew H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont5386. APPENDIX E INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Company Sanitized. Does not contain TSCA CBI 0 9H-02:4D5a1y6G:ovSaugbcehSvtoundiyc TinonRitcsityithOne-Generation Reproduction Evaluations DuPon5386 - INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA EXPLANATORY NOTES Critical Dates Day 74 Manadlearaenrd feempaleoasrar"tsrtedmesoeivgedndatferdofmorsrteupdryo"diuncttihiosn aepvpaelnudaitxi.onsClwienricealco-housed Observations recorded during the cohabitation and post-mating periods are reported in the Reproductive Toxicology section. Day 80 Ophthalmology examinations were conducted on ras designated for the 90day exposure period and the one-month recovery period. Day 91 Male rats designated for the 90-day exposure period were sacrificed. Day 93 Female rats designated for the 90-day exposure period were sacrificed Day 122 Ophthalmology examinations were conducted on rats designated for the one`month recovery period. Day 125 Male and female rats designated for the one-month recovery period were. - sacrificed. Day 181 Male and female ras designated for the 3-month recovery period were sacrificed. Any clinical sign observed on consecutive data collection days is assumed to have been present during the interim between observation days, and will be reported as having been observed over the period from the firs-last day observed. Ophthalmology Evaluation observations and Clinical Pathology Evaluations are documented as Clinical Observations and interrupt the continuing clinical observations. All ophthalmology observations from test days 80 or 122 are those observed during the examination by the veterinary ophthalmologist. (Company Sanilzed. 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Lai a 8gs - 3g : i : : f : i 5 2 i, a8 g a fn, gle, Gast FIs Be Ie Die Desdener Bee Diop I3iden Diisidis - e $33 3% 1 gob dfFs 1fi1f1i1 1 I I IRERR E 2P5o 2 19702 8 7 did h Hlb: L ihEe Ba 0 Edy fhe dp GE gn ann BFEg5 gfy fdapfld8p 8a5glHslheiegahlEl gdof,odasllf asahiinets fHlihldae: FREE RRR Brn BiB Gg Eiigagaagaitihg seis Rie sraldt 1 olgdit = HOHE Ham iil HHS HINER HEH 5H 2 E#E 3: 3EE:E iI 38 33 :3 l Progogooz ERE i 1 I. PN . 8 i a 3z 8 8 & i |& . Hi Ef fx 38 LJ BF 3he3 Leen Las Thedls Din Rat Bax PEELE Toh, f ivi hini bil. : IF BPP opi oRR, BBY 88 a oF iL238 Lon x38 2% flEe85 428 Lgdoend BBiE: sHihaoudl dagilt ial 4al iagl 8B7E gE hsE E arial safd finlanid nif oint 5 8 5 7B0EF BpI27B FIEEnE d nGEaPRtF NEEBRE tt BRR Sfae" EGEBnLeE BtY ia BWhHuOl Iin HanDn 3 4 i: : iif 3: FI FE if 3 - 3dpl fcEx oz zo: iio E oz 01.-2D0a51y6:GavSaugbeehSrtouidyc TinoxRiactistwyithOneGeneration Reproduction Ealstions DuPont 5386 APPENDIX F OPHTHALMOLOGY EXAMINATION REPORTS "ompany Saniized. Does not contain TSC car - 9H024D5a1y6:GeSvuabgcehrStoundiy iTnonRiacts ith One Generation Reproduction Evasion Dupones386 - OPHTHALMOLOGICAL EXAMINATION REPORT (TEST DAY 80) NAN6CE1YY1E9MMC.ALBISRNSOIACMCFBHOEURRSGAE,NTTIVSMLAADLV,SEMs. BETHESDA, MD 24816 srovs sommaton: Sswpaoyn{NG) ShyDior: Greg Ladies OPHTHALMOELxaOmGinIaCtiAoLn DEaXtAeMMIaNrAcTI3O,N20S0UMMARY FSMeeExmTaHleODS: oCVIdrite OphthC6aa6lmpoemepy foGhlo6ev1ini1% TrDCopioicfanmiavdenamlydrdieagsiesneratiOoSn - cpoobbmhiamaiEOmnsNotoTcmSallpDocbeIeSiwCGoaaUnsrSdi.SneInoONiNorecdaowmipstohauursedetriinidnede.beAnaloastherisschnmmraytbsheedanteiaa0.brad sovB0itbhlee KogoR anlY i 0] Date gam! - smpany Sanitized. Doss not contain TSCA CB Ey 90204DD5a1y6:GGoovSaahgecnSolnyyeinTRoRatssivithOOnet GenmeiroinsRRepordodcsiioonnEEcvhinoss OPHTHALMOLOGICAL EXAMINATION REPORT (TEST DAY 122) NANCY SEBVIREOACMALBISENSRIACGC,FHOUVRSLEADTN,TISMMAASLV,SEDACY.0. SETA MD ie sro mronion: SfsuoeyreI onD t). OPITHALMOTLeOmGaIsCioAnLEbXAtMIANpATI5O,N30S1UMMARY METHODS: nics Ophbtmscpy loin 194 Trpeid mdrias commf e IsCussir on -- pDuupromsittes_ ho 2 iplomate, A.C.V.0. Company Santzad. Doss not conta TSCA Cal --- ZH9202D-4eD5a1yy6G:GaavvSaauggbecehSSrutouunddiyycITinnoRxRaiacttisstwywiitthhOOnnee-GGeenneerrawtiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonntt:55338866. APPENDIX G INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH --_----- strm- om _-- `Company Sanitized. 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Bveainn on S yoa nd oSani1 se oo Taeen a PEeE HR E R -- Company`Sanitized. Doesnot. contain TSCA CBI 24516 Soto Ts INDIVIDUALFUNCTIONALOBSERVATIONALBATTERY ASSESSMENT Molaro V: 100mg ye -- gL5S5g2:5 E5E 3zy%:Ez a -- ean ot Deaton 22F'E FE Se 28b&y|EB weed izes Bearis en Fooiea ie 0 eoT e oo Bae a Phe ~ "25 DWeeekir1n3 sa oaarns oE0 EeR0 .0 vvaee r o0 01ea0 0 Sie "2s Drans wai Pain S 0 oae Te 0RT oHie Siar 514 Beaise -- 0ia0ina ee 0F ET oAe atti Bwaeites FSER ome EREEN - S*R Sacrificed -- in exti remis rpriortoevSaluaitio,n. - ~ompanySanitizeq, Poss notcontan sca cay 9H240516::vDSaugbscSttryouiyciTnoxRiactistywith One Generation Reproducive Evans Duron:s386 _ INDIVIDUAL FUNCTIONAL OBSERVBAATTTERIYASOSENSSAMENLT MaleRatsGroup VI: 250myn MANIPULATIONS NMAMONITOR 5820 5 34 3 2 $288532 2238 ==3B2E::EF 3g E S651 BWeueske1s3 oouoi Recovery 00 oWiEE 43165 Busine Wes 13 o izioeloie 0 a1E oo 520 Recoery Basin Week 13 oo oem 0 oi oo 0 643225 BRaesceolvienrey * oo WTR Week 13 0oa0 ie - 643234 ReBcuosvienrey oooo 0 00 11 #:iSea oilia ReWceoevkery 649236 Bsn o o0 a 0 oo o 0 o0 o RWeecsokve1r3y 665258 seine oo 0 0 0 1 00 oo Week 13 Reconry oll0 ie0 0001 0 01 645266 BWueseikn1e3 Recovery 0vi0es0 IE 0 0ey 643256 BWueselkin1e3 oWoT 0 ooaa 01 643316 BReucsoivnerey Week 13 0 oi 0 0 W in1 0a 01 Recovery oo 0 I ~ Additional cservaion md Prosi --_-- Company Saniizad. Doss nol containTSCA GI R 0D Gongse Sy Ratip hOr Grr en ieve - PE INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT i =E 5 0% 22 25 2 HS g fd 22 2 vad Nene Rg EOL is: Sa .14 in LT Poa T --_-- e `Sacrificed in extremis prior to evaluation. Company Sanitized, Dos,notcontain Tsca cay 20H-.24D5a1y6G:GaorvSaugbetSvStounydiysniTnRRoatcvwiithOnneeGGeenenreuoionn ReporsoBxautioonss DDuubronesintgs - INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Female Rano IV: 25 min MANIPULATIONS INMANONITOR =F > zg et Busine Se25g2s 3 22WT2R5 38 EZ % 3 228Sa8 % G34 BWWeeaeeksk t1133 * S ooeo owoee0 Ga3364 BWaeseelkin1e3 ooeT o 0oao cn BWeeke13 I VILE) $oeo 45385 BWeueik1n3 w e0 e0 0p0e0 - 43300 BWeueik n13 ows R0 0 wooeoe ca56 WBeoekse13 P ooe0 owis oovd 43410 BWeaeskle13 ooioe 0 S ooY0 603453 BWeaekne13 wo R0 0 A ooo cose WBeaekne1s w0isi 0 0 ooiioiv i0e *Sacrificed in extremis priorto valuation, Company Sanitized. Does not contain TSCA CBI 703 EE -- 92204DD5eay1y6OGroaSgbaeevSondyysinTnoRxiaacsitwyiithOnneGGeneenraetoionnReprroodudcstive Evxaalsrionss pDruorownsst3at6s INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT `Female Rats/Group VI: 100 mg/kMgAidNaIyPULATIONS NMA MONITOR 8%8E:2ri3- Imzz soc:z& zt2 om Basins 202838 E2F WT O238:2 2: 00 63 iwenae13 wee 13 ooooo I BoE o 0 oo code BWaeie13 643267 Bains [ EEEI 0 00 o00 0 00 4392 B[iie wears w 0 oeo 00 Ioo [a - 43405 [Bile ioeo ooet Bato oT oo i wo ise 00 Goer B[aoiens o00oo oofioin a 6022 BWaetaon1s Week 13 0wi4de0 0 00 oo 00 64389 BWaeeairosn o0 lin0 00 00 o0o -- --_-- Sompany`Sanltized.Doesnot contain Tscacer ZS1D2D4G 516G:orSguecSSounydiTRoatistviithhOOneGGesresrnoionnRepprrocdtve BBoibsotosns pDuruormeessiss INDIVIDUAL FUNCTIONALOBSERVATIONAL BATTERY ASSESSMENT FemaleRasp Vl: 250mie MAN=IPULATIONS NVA MO5TOR gEe5e2s &8 3&2y o2 &E 53 Baie 802o288o2 oF=E 3E%zoi 0E% 02% Rweeeaksr * 3307 Buel ooooo0 ooo o[I o ooo RWeeceoksr cs puis ooooo0 ooo oooooo oo wReecaorrersy 645558 Buln oo0 o 0 joe [oIoE o [EE ~ Rewenaers 23 Basle oooooo ooo [o I e wi Week 13 000 000 346 BWReeacoaivee1r3y * Recovery [v0 0E0 I00 [EI oI 0 o0 0 ooo G34. wBueseinse Recnery o0o0o0 000 o oio oo 63156 B[ uelon o0 o00 Booey <0 0 0 oa 1 o 00 G47 Bwaesai1ns Recor o0 o0o0 [EE oooooo 0 oe ssa Wueecki13 Roary ooooo o ooo oo a a ooo ~ R m orte oo nte hsmciemne. That Depron ISRITY _-- H24516: Subchronic Toxicity Z920:-DDaayyGGaavvaaggeeSSttuuddyyiinnRRaattsswwiitthhOOnneeGGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonntt55338866 APPENDIX I INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENTS - Tw Company Sanitized. Does not contain TSCA CBI H9-02-4D5a1y6G:avSaugbeehSotnuidcy iTnoRsaiicsiywith One-Generation Reproductive Evaluations Dupon-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Baseline Male Rats/Group I: 0 mg/kg/day Animal Number 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 1 Successive 23 10-Minute 4 Intervals 5 $3 48s 447 80 38 200 193 10 6 397 42 401 436 306 408 291 360 4 127 S00 299 401292 28 241 319 306 235 179 "43 365 WT 204 247 103 22 66 al 1 339 a61 234 25 359 104 156 0 34 17 6 Tom 27 en 0 807 1 1440 10183 8173 34 1453 165 139s ssa 09 0 106s - Male Rats/Group III: 25 mg/kg/day Animal Number Successive 10-Minute Intervals 1 2 3 4 3 6 Total 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 91 2 232 6 2 1 23 56 0 2 6 7a 0 1140 91 306 29 5 361 2% 2% 35 5 5 9 1012 [I 38 306 171 34 486 468 48s 259 1 45 1 son 8 st 03 245 se 6 3/268 12 100 1 2 170 1 ea 487 382 305 160 464 454 386 189 9 26 20 1363 32 `Company Sanitized. Does not containTSCACBI em--tr 9H02-4D5a1y6:GavSaugbcehSrounidc TnoxRiactistywith OnGseneration Reproductive Eraluations Dupon:5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS(sec) Baseline Male Rats/Group V: 100 mg/kg/day Animal Number Successive10-MinuteIntervals 1 2 3 4 5 6 Total 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 454 443 424 368 329 366 488 3n 432 353 386 385 278 299 241 262 406 304 366 292 370 344 257 153 135 53 76 277 13 185 122 399 151 17 7" 5 3 us 49 2 5 3 1340 260 258 2089 29 4 1143 0 2 839 1 6 789 30 0 716 2 183 1188 37 53 1156 17 n 988 6 17 877 - Male Rats/Group VII: 250 mg/kg/day Animal `Number Successive 10:Minute Intervals 1 2 2 4 5 6 Toul 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 357 454 434 415 405 312 305 375 434 433 267 366 2m 267 336 309 159 255 361 280 23 33 366 239 90 1 232 124 298 195 147 1 129 12 251 107 10 6 41 n 0 0 870 256 120 1801 0 0 796 102 24 1164 49 60 1343 38 238 1045 1 6 612 0 2 990 26 2 839 0 s 770 _-- Company Sanlized. Doee snotcoe ntain sca ca 29H02.-2D4Da51y6GG:aavvSauggbeechSSruoudndiyyciiTnnoRxRaiacttisstvywiitthhOOnnGeeeGennereatoionn ReprrooducctiiveBEarsatluitoonns DDuppoonmtss3i86s - INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Baseline Female Rats/Group Il; 0 mg/kg/day Animal Number 664433333360 664433338777 643405 664433042155 664433444286 643453 Successive 10-Minue Intervals 1 2 3 4 3 #0 9a0 2 wm 2m 0 oq 0306 2136 1130 1i96 mo20 Mm2o6m0 2s wo 257 7 ad6e 9B27a9 19 wm 01 24 ig 28 d3q 6303s 2 26 200 46 2s 230 6 Total 3[ETgr 205 1m03s a27 13gos 7 193 la as 0 0 1303 om - FemaleRatsGroup IV: 25 mg/kg/day Animal Number 646343332241 646343338604 646343339809 60339 646433441303 643458 Successive 10:-Minute Intervals 1 2 3 4 3 6 Total M WB2s6130 m Ww q26 Ww ss 0 no5 1n7s0o 5 op BB0 27 2 a8 2289 21 2namsy wM1a6s0 m 20 wm3 16s s s10nn 4as223%66 2663 ass ars5 7[IBHn a Bl I; 2 3 7 om --_--_-- CompT anyST anitzed. DeoesenorcconttainTSCA cay S0H-e -2D4a51y6:GaSvuabgeeohSvtounydcy iTnoTrRiacktitsywiithhOOnneeGGeenneerraattiioonnRReepprroodduuccttiivveeBEuvaallautatiioonnss DDuuPPoonmte-s5a3s8s6 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Baseline Female Rats/Group VI: 100 mg/kg/day Animal Number 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 1 Successive 10-Minute Intervals 234s 6 Tow S06 BL ass 24 ase 74 404 0 438 10 40 2767 37 766 a8 360 13259 25 368 20 12 or 4 16 1206 19 17% B70 ar 294 3 204 23 200 27 125 op 22 51s 398 261 23 2 32 268 3 12 33 nos 2g M8 362 297 198 oe 13 18 13 10 [a 85 22 193 - Female Rats/Group VIII: 250 mg/kg/day Animal Number 643345 643347 643351 643358 643423 643441 643444 643457 643474 643481 1 Successive 23 10-Minute a Intervals 5 416 78 324320 251 18s 390 48 348 7 3929 38 361 312 120 33 5 341 68 320189 24s 36 2412 162 10 200 7 331 43 7 26 M2 276 28 148 40 5 32 2% 6 5 28 38 248 23 0 18 6 Toul 351 2140 170 25 1g00 1 as 73 108 3m 0 1088 7s 19 4 ms 2 nm - CompenySanitized. Doss not contain Ts cay wm 9H-02-4D5s1y6E :GavSaugbeehy Srtoundiyc iTnoTrRiatcsitwywiithhOOnnGeeeGneenreraattiioonnRReepprroodduucctiivveeEEvvaalluuastiioonnss DDuuppoonwts5s3s8s6 = INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Week 13 Male Rats/Group I: 0 mg/kg/day Animal Number 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 1 2 Successive 3 10-Minute 4 Intervals 5 6 Tow as a7 419268 378263 430316 8426s 34205 20 304 Im #0 3 316 a1 22 56 190 ss 205 191263 13 1487 2600 297 187 303 26 120 200 1523 20 esr Bam Biss am g3 ar ise 9 ss 204 201 ass 139 4127 Be os) 2 1008 2m14 oa 203 nsss 2 01s 11s - Male Rats/Group III: 25 mg/kg/day Animal Number 643173 643179 643180 643228 643240 643264 63272 643290 643292 643308 Successive 10:Minute Intervals 1 2 3 4 3 01 ar 260 36 226 24 14 206 4 176 230630B1a3e6 3290 ow 133 1s 436893265312000 a8 a8 18 14 98 368 287 260 126 127 1s 4 1 7 40 36 A837 326 ies 0 1s 6 Toul 2 ey 55 1309 88 iss om py jo pm 12 4m 6 900 4m sa 136 47 es - -_-- Company Sanitized. Does not contain TSCA cay 9H0-R-2D5oa1y6n:GaevSauegbecShSrtlouidyycbiTnnoxRRiauctlistwywiithhOOnnee-GGeenneerraattioonnRReepprroodduicctiivveeEEvvaalluuaattiioonnss DDuuPPoonntt53583686_ INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Week 13 Male Rats/Group V: 100 mg/kg/day Animal Number 643175 * 643224. 643243 643247 643250 643257 643275 643311 643314 643318 1 Successive 10-Minute Intervals 2345 6 Toul ue wo 3/303 22 B28 20 29 al 300260 207 341260 25 405368 33 306 189 129 Is 4 31 Bl MS 33 :- " 4 4 98 1418 249 18 185 1457 9 22 025 66s 12 iss 1387 15a 200 0 1180 21 3m 1m 1m 1s 125 91 oss sm 267 123 1g 265 um 1784 - Male Rats/Group VII: 250 mg/kg/day Animal Number 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 1 Successive 10-Minute Intervals 23 a 5 6 Toul 85 147 3830 4s 40 ou 221 4 138 3 s08 13 1559 40 296 28 23 249 250 28 183 15s 23 29 1390 66 1231 29 7 395298 6 230 3 135 6 138 13 ase 28 1224 304300 37236 16 177 150 1s 92 10 212 1214 16 1021 48399 42 3s 369 29 305 105 240 288 160 1911 269 1768 = *Sacrificed in exremis "prior to evaluation _-- CIosmpany Sanltized.DoesnotcontainTSCA cay 9HL02-6D5a1y6G:oSvuabgchSrotniyc iTnoxRiactistywith OneGeneration Reprodsctive Evaluations DuPont5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (scc) Week 13 Female Rats/Group Il: 0 mg/ke/day Animal Number 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 Successive 10-Minute Intervals 1 2 3 4 3 a3 29% 402270 19 R20 189 167 7 190 35204 22s 242 2 127 07 6 190 402 265 20 3993255 205 2 141 160 43370 aw 350 2 lag 2 2 2 206 6 4 M0028 mons 103 Total 50 a 29 1620 m4 12% 12 13m 2 12s 152 1581 0 1m 3 69 0m 24 ps2 - Female Rats/Group IV: 25 mg/kg/day Animal Number 643321 * 643324 643364 643380 643389 643390 643396 643410 643433 643458 `Successive10-MinuteIntervals 1 2 3 4 3 6 Total . 499 . 346 306 305 361 . ve 253 2085 ar 396 47 231 a7 202 2m 196 18 102 14 146s 102 1220 283% M28 306 246 148 87 2 154 no 1301 Isa 1300 S20 420 49 3m 26 34 20 29 6 138 136 135 22 170s 336 4% 13 3s 20 22 199 2 1 5 76 37 a0 14 = *Sacificed in exiremis wpriortoevaluation - Tm Mmpany Sanlized. Doss not containT5c4 cy 9H0A.SD1a6y:GovSaugcehrSoundiyc TinoxRiactistywithOne Generation Reprodseive Evalustions DuPones386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Wee 13 FemaleRats Group VI: 100 mglkglday Avimal Number 6433332232 664433336667 646343430992 66133446612 646343448792 LzSuccessiv3e 10:Minu4 te Ins ervals 6 Tom 2sa9s6 a7 301 e 0 sus 1q9e 4462330 230a9 a2u4ss 927s 2a56 s18e1g7 wWs 630 0 6231 2a 0 w18 tn e oas d6 2o5w 23 m2 W1s7 aums 13s 2B 4 17 B730 on1muss om ueme - Female Rats/Group VII: 250 mg/kg/day ANnuimmbaelr 664433334457 664433335518 660433444213 646433444547 664433448714 12Successiv3e "27 n1ss 30026W3w 8 9 Ws2 193 wasmaoru 228 W 2 268as 10:Minu4te Interval5s a1e0 om a8s ooms mw4 usus 26 14ss wm4%22 6 Iw a2s6s usmg a 15 o1s017 92s ao0n u6y 1sse sa 9 - -_-- Sompany Sanilized. Does not containTSCA CBI H9-0o 2-4D5a1y6:Ge avSaubgceShSrtooundiyyc iTnoRxRuiatctisstwywiithhOOnnee-GGeenneerraattioonnRReepprroodudcuticvee Evvaalluuaattiioonnss DDuuPpoonntt55338866 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sce) Recovery Male Rats/Group I: 0 mg/kg/day Animal Number 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 1 Successive 23 10-Minute 4 Intervals 5 79 187 13 423 23 1s 7 85 100 Lam 10 13 296 14 2 138 2 ol 286 187 32 109 10 107 11 2 1s 329 157 3/200 164 194 197 2 147 126 268 B 18 26 18 19 129 22 s 192 6 Total 8 8: mB 1264 0 939 137 ges e795 98 133 25 1209 25 1300 108 830 205 1446 - Male Rats/Group VII: 250 mg/kg/day Animal Number 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 uccessive 10-Minute Interval 1 2 3 4 5 28193 2200 14 17 150 200 17 174 3100200 22192 23 202 04 193 135 139 197 168 9 2 a7 3 53 67 8 207 3B' 2m 13 29 15 59 160 130 99 44 32 2 304126 ass 132 127 8 109 13 6 Total mn 1023 192 125s 16s 11a 10 1068 ER 54 oss 193 1258 70 as 13 1031 1s sss _-- ~mpanySanitized. Doesnotcontain TSCA cal 9H0--24Dm 5a1y6G:ae vSaugbeehSrtounddiyyeITinnoRxRaiatctisstywwiitthhOOnnee-GGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuubPoonnte-s53i8s6s INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Recovery Female Rats/Group II: 0 mg/kg/day ANnuimmbaelr 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 1 S2uccessiv3e 10-Minu4teInterval5s 6 Tou 307 160 46 132 ane oe . ie 74 201 1020 , " . 381 246 3508s 201 191 168 109 160 128 1293 79155 1034 208 137 B36 167 21 65 26 110 79 17 704 11263 2 330 26 28 1 160 707 9% 989 198 76139 131 3204 387 267 177 166 am 234 210 1067 14 90 1318 -- Fenuale Rats/Group VIII: 250 mg/kg/day Animal Number Successive 10-Minute Intervals 1 2 3 4 3 6 Total 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 269 25 39 294 146 194 0 95 0 50 97 430 38 28 20 132 55 267 166 38 120 31 192 oss 60 2 379 254 233 2s 254 110 27 2] a9 187 1356 1712 ss 345 216 185 56 38 29 76 0 7" 1 Is 763 7 aa 25 27 ass 12 an uz 61 B14 121s 7s oie 906 - Scxremeprioreosad in. -_-- (Company Saniized. Dossnotcontain TSCA C1 TE RSH0:2-a4D5a1y6g:GoSvueabgcehrSotnduidyyITionnxRiRcasitsywwaitthhOOnnee.GGeenneerrattioonn RReepprordoudcutiiivve EBrvaalhuaattoonnss DDuuPpoonnt35338866__ APPENDIX J INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS - CompanySanlized. Doss not contain Ts cay H902-4tD5a1yh6;GaevSauegbeehSrStounhdiycyiTnoRxReitbcisstwywiilthhOOnnee-GGeenneerarttiioonnRReepprroodduucctiiivveBEvvaallutsitoionnss DuDuPpoonntt55338856__ INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Baseline Male Rats/Group I: 0 mg/kg/day Animal Number 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 Successive 10-Minute Intervals 1 2 3 4 3 6 Tol ST 8 sl 24 130 141 23 3 16 13 4 236 2a 2413 88 93 es 100 24 109 a 79 4 sso 0 479 9% 28 103 15 19 m2 us 120 13s 7 67 6 133130 42 134 161 136 140 68 si 4 666 4s 46 121 144 ue ur ue 0g 3 m2 13 ssa 0 an - Male Rats/Group III: 25 mg/kg/day Animal Number 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 Successive 10-Minute Intervals 1 2 3 4 3 28 14 7s 14 12 134 wy 0 3 noo 8 os 46 120 137 8 31 5 6 Wor 62 23 es 3 10 B36 1s 5 0 47 us 1 9 2 18 9 00 102 140 106 142 us 8 om 6 Total 9 369 0 as 13 369 [I 5 a0 FR 6 3s 6 507 1 uss 3 a6 `Company Sanltized. Does not contain sca cy - Tw 9Ho0--2D4ma51y6SG:eoSvvuaabggceehSrSotunuddiyciTinonxRRiacaisstwywiitthhOOnnee.GeenneerrattiioonnRReepprordoudccivievEEvvaalluuaattiioonnss DDuuPPoonntt5-3s83686_ INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Baseline Male Rats/GrouVp: 100 mg/kg/day Animal Number 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 1 Successive 23 10-Minute 1 Intervals 5 B97 0721 2 os Be 6 13 135145 146 21 130 ns os 2 2g 1 2710 18 4s os 57 4 9 28 urns WIS 140 8 90 26 38 moos og Ho ise 2 30 19 3 12 6 Tow noo ue 7m 5 ssa 2 30 13 43 1 300 78 30 26 sso 4 ans 19 a7 - Male Rats/Group VI: 250 mg/kg/day Animal Number 643151 643165 643220 643205 643234 643236 643258 643266 643296 643316 1 Successive 10-Minute Intervals 23 4s 16 181 130139 134 7 ss 67 1 ass 2421 "Lo sa 10 4 es 1 oR 12137 44137 12 4 10 48 72 2 124 3 43138 4s on os 3 4 122 iss 12 25 130 2s 9 ul 71 6 Tom 0 5% 90 gs 0 30 1550 6 63 us sw 6 301 550 9 318 8 29 - - `Company Sanltized. Does not contain TSCA CBI m H9-02-4D5a1e y6:GavSaugbeehSrtocundiyyc iTnrRiRoactsistywwiilthhOOnnee-GGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonnte-s5i3g86s INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Baseline Female Rats/Group II: 0 mg/kg/day Animal Number 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 1 Successive 23 10-Minute 4 Intervals 5 21 124 136 47 21 us 13 B31 M215 us 1s 10s 109 ISL ISL 125 1s 137150 130 2 2 ns 127 5 1543 100 108 132 135 128 126 139 4 Mow 79 nus os 140 100 136 42 1s 20 24 ass 6 Toul 4 400 7 se7 nosis 8 687 37 gor a0 sa 0 si 125 803 4 sal 15 sig - Female Rats/Group IV: 25 mg/kg/day Animal Number 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 1 Successive 23 10-Minute 4 Intervals 5 16 138 M1167 19 16 148 174 19 168 106 124 100 120106 130 32 2 B 106 129 36 19 14 129 138 18 161 128 9 12 148 149 46 151 12 7 88 9 1 120 149 12 21 a2 ou 126 4 9 8 6 Tow 762 104 910 8 an 2 sm 2 7m 36st 3 531 2s 2 esi 2 38 = Sompany Sanitized. Does not contaln TSCA CBI - mw =9He 0--24D5a1y6G:SaovvSauabggceeShSrutoudndiyyciiTnnoRsRaicseitywwiitthhOOnnee-GGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonnt-55338866 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Baseline Female Rats/Group VI: 100 mg/kg/day Animal Number 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 1 Successive 23 10-Minute 4 Intervals 5 7 67 Be 1s 7 7 S60 1 15 109 155 13 0 124 12 95 82 ss 34 M912 nso 17 107 7 131 us 50 132 12 139 BI 17 7 31 8 25 155127 50 192 na 103 19 15 6 6 Tom 1 4m 23 am 14 aa 16 ass 3703 LE 13 300 18 457 2 37 150 647 - Feiuale Rats/Group VIII: 250 mg/kg/day Animal Number 643345 643347 643351 643358 643423 643441 643444 643457 643474 643481 1 Successive 23 10-Minute 4 Intervals 5 136161 12 129 134157 146 st 166 9 471s Iss 139 12 9 138 6 126 54 M0 M3129 12163 107 13 1 6 16 125 46 131 132105 13 9 1 3s n 21 us 13s se 144 134 6 19 0 25 6 Toul 164 92s 3 aw 146 sss 4 an 71 7m 5 asa 1 a7 59 sed 7a 4 ssa = - Tm `Company Sanitized. Doosnotcontain TSCA CBI 9H-02-4D5a1y6:GavSaugbechSrtoundiyciTnosRitcstywith OnGeeneration Reproductive Evaluations Dupo 5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Week 13 Male Rats/Group I: 0 mg/kg/day Animal Number 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 Successive 10-Minute Intervals 1 2 3 4 3 8 6a 3412s 19 150127106 RE 0722 2419 109 22 1% 3 14166 135 mass ea wom 2 14 9 us ous 99 125 16 7s 853 107 2 106 48 03 77 a 97 6 Total 319 es 7 138 74s 95 620 19 601 nos 0 597 7 els 8 608 2 609 - Male Rats/Group Ill: 25 mg/kg/day Animal Number 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 Successive 10-Minute Intervals 1 2 3 4 3 6 Total 127126 126 uss 109 60 LE 101 2% sis 28 160 10 90 99 103 10s 95 e651 100 88 550 636 uo a 9 12 89 9% 88 6 8 8 63 48 sie woo on 48126 101 6 5 9 sl a3 8 4 39 129 1s 42 97 126 94 0s 84 15 64 ns 24 450 - Tm Sompany Sarid. Dossnotcontain Ts csr 9H-02-4D5a1y6:GavSaugbeehSrtaundiyc iTnoxRiactistywithOneGeneration Reproductive Evaluions Dupont 5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Week 13 Male Rats/Group V: 100 mg/kg/day Animal Number 643175 * 643224 643243 643247 643250 643257 643275 643311 643314 643318 Successive 10-Minute Intervals 1 2 3 4 3 . a .- 33 441300 13 139 2 130 12 3 le 2 12 2 18121 19 m2 109 04 12 23s 108 8 121 1s 120 127 97 no 1 137123 138147 15 15 3 136 126 91 6 Toa 6 68 1s 9 16 323 123 742 1 8s en 75 687 9 65 140 80s - Male Rats/Group VII: 250 mg/kg/day Animal Number 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 Successive 1 2 3 94 20 127 129 39139 024 M418 18 132 6 6 155 144129 43150 103 BI 102 Hoo nloo00 109 128 9% 10-Minute Intervals 4 3 6 Tol 28 6 6 346 9s B en 121 102 39 ess na 12 S602 ssa 14 om 92 03 3 oa 123 oo 7s 6s 6 9 517 00 106 86 61s 59 M6 114 62 "Sacrificed in extrmis prior to evaluation - `Company Sanitized. Does not contain TSCA cat =m 9H0:-2D45a1y6G:avSaugbeehSrtoudnyciTnorRiacsitwyith One-Generaion Reproductive Evaluations DuPont5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Week 13 Female Rats/Group II: 0 mg/kg/day Animal Number 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 `Successive10-MinuteIntervals 1 2 3 4 3 6 Total 139 BL 124 6 84s ms 88 36 1s si 699 JETER] 161 147 146 0 12 8 13 40 123 700 sn 47 na 18 1718159 2 Isa os 135 no 142 607 90s nous 97 5 166 130 17 25 31 5 an 6 41s 122 4 uw 66 5 9% 7 oan 3 1s 60 - Female Rats/Group IV: 25 mg/kg/day Animal Number 643321 * 643324 643364 643380 643389 643390 643396 643410 643433 643458 1 2Successiv3e10-Minu4teInterva5ls 6 Tom se we we 25 134 2130 129 19 146 19 134 14 127 57 705 ss) 13514 9% 19 1212 1s 107 87 26 58 601 81 es 13 127 13 9 e731 6 121 120 739 4 8 24 183 23128 Be 2 1s 8 137 13 10s 2 123 5 767 392 W313 ms 26 26 128 sal * Sacrificed in exiremis prior to evaluation --- mT feompany Saritized. Doesnotconten Tc cay 22H9-0-2-D4Da5ay1y6GG:oavvSasugbgecehSSvttouunddiyyciTinnoRxRaitcssiwtwyiitthhOOnnee-GGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPpoonmt55338866 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Week13 Female Rats/Group VI: 100 mg/kg/day Animal Number 1 Successive 23 10-Minute 4 Intervals 5 6 Toul 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 65 se 161 10 si 2 5 13 1> 12 8 m0 32123 105130 129 7 108 27 us a 34 sol 62 13 129 8 se 8 37 sa m2I8 106 105 146 145 18 128 20 104 575 13 ns 6. 2 44 1S 163107 87 23 123 56 121 2 69 9 61 139 108 3 34 6s as - Female Rats/Group VIII: 250 mg/kg/day NAunimmbaelr 643345 643347 643351 643358 643423 643441 643444 643457 643474 643481 1 S2uccessiv3e10-Minuate Interva5ls ue plo 124 100 7s 21 7% 138136 135 75 9 12012 1 12 156 127 9% 93 os 19 16 136 100 0012 13 95 se 90 24 8100 12 13 85 1343 2s [I 4138 10 12 127 6 Toul 100 sn 23 503 135 608 18 587 25 sie 7s ss 4% 4 sel 9% 407 4s 718 --_-- Company Sanitiz-- ed. Doesnot, contain TSCA cay H5-02-4De5a1ry6S:GaaSvugabgceehSrSotnudidyciTinonxRRiaactittssywwiitthhOOnnee-GGeenneerraattiioonnRReepprroodduuccttiivveeBEvvaalluussttiioonnss DDuuPPoon-e55338866 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Recovery Male Rats/Group I: 0 mg/kg/day Animal Number 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 Successive 10-Minute Intervals 1 2 3 4 5 6 Toul B34 19 10s 8 0s 6 el se 65 ses ss 30 2 Bo em m2 me 77 sol 81 S486 asi 15 12 46136 7s 99 m7 71 12 48 560 70 64 400 12128 9% 100 17s 9 89 1S 100 ode 669 "20 21100 8&7 89 87 oe 13 6 su 1s ed ~~ Male Rats/Group VII: 250 mekg/day Animal Number 1 Successive 10-Minute Intervals 2345 6 Toul 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 M4BL123 136109 86 00 136 77s 102 18 ee 687 1012105 B14 98 126 9% 1s 60 95 88 ea % ue 6 9s se 92 aa 6 100 7 ul 39 505 22 i648 oe 3s 76 so 3 90 503 49 4s 28 ss 2468 sl 75 % 36 6 6 93 sx 7 4% - Company Sanitized, Does, not contain TSCA oy Tm 2010-24DD5a1y6G:GaavvSaauggbeecShStrtuoudrdiyyciiTnnoRxRiaacttisstwywiitthOOvnee GGeenneerratsiioonnRReeprpordoudctuicveeEEvvaalluuaattiioonnss DDupuopnot5n38t6 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Recovery Female Rats/Group II: 0 mg/kg/day Animal Number Successive 10-Minute Intervals 1 2 3 4 5 643330 643336 * 134 123 101 100 58 I - 643377 643387 643405 643415 126 132 98 114 116 152 18 132 101 70 126 106 m3 69 102 135 152 129 155 66 643425 664433444286 139 132 108 76 92 1u5s7 1as3l0 18247 112269 6642 643453 130 129 105 19 87 6 Total 155 671 . 102 688 126 699 14 530 5 642 84 631 110044 676167 55 625 -~ Female Rats/Group VIII: 250 mg/kg/day ANnuimmbaelr 1 S2uccessiv3e10:-Minu4 teInts ervals 6 Toul 643345 643347 643351 643358 643423 643441 664433445464 643474 643481 153 137 154 142 nur 18 30 0 103 12 8 138 99 43 126 56 101 nus nz? 122 0 69 270 47 43 520 2 129 605 52 32 509 2 121 637 142 85 38 50 2 84 421 s 149 as144 255 621 893 o3w4 523m3 49125 126 66 28 9 sol 136 109 82 93 85 87 592 Sacrificed in exis prio to evaluation. --_-- `Company Sanitized. Doesnot contain TSCA cat 2-9HD02-4aDSa1yy6G:GaavvSaauggbeeeShSvttouunddiyyciiTnRoRxaaitscviitthhOOnneeGGeenneerraattiioonnRReepprroodduvcitivveeEEvvaalluuaattiioonnss DDuurpoonn:55338866 APPENDIXK INDIVIDUAL CLINICAL PATHOLOGY DATA - ComeanySantzad.Doss notconan sc cay 2H$002-D6D5a1y6G:GaaSvvuaabggeeehSSrttuoudndycyiiTnnoRsRitacitstsywwiitthhOOnneeGGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonntt55338866 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES JBNoERrRT NT-HEMWWOLk C1 OB7IY0FDC11 a Sneoacstserasrspelae received for cessing RTaoaotmpnileaekcenonndooiretinooGnro hpoaexsrfofolobrvmeeltdsesstrienagcer chan of equal enR anbtlietl yionoal tekesrentitniecient grenter onan to soderate Sadtv"idRCsXDal s1emssetaaoltobeolyocovodinvdeeiettsi:conount fe hei WoBIorCn D epTeeedancecCioolrmppduuisascctuurliiaabrruthhieaossnsogowttooibbdiitnnh concenceation -- AAWEoEC D- aSwbbheeiooetluuttbeeloonsameuttcirecloalplnoicctyhiem(8S11ofmorms) WARovDCT R205 aGibhmaaoootlniitvvsee Shmoiute ssnhoteonevtoinncresyodpoehhsiiiell precureer NJAIimEns 1 SSahheaaoooiiluiuttveee bbllaausrsogepehiTsloncattaastyneeed cell BSFrEiETD pSBphaeacotiheailsleomcbsioesmrceveartiioannsen Jeukoryie WXCT hauhpuemriseeagmeTnrmipevdecmyeecet.caphil - Company Sanitized. DoesnotcontainTSCA CBI 29H002D-4Da5a1yy6G:GarSviuaabggceehSrStotunudidyyciTinnoRRxaaittcsswwiitthhOOvneeGGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuubpoonntt55338866 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA [EE ---- EXPLANATORY NOTES (Continued) Snbividuas Res 100d Cest orphstony vaiuans we D Sereoan rwong1 pi aeonn isia oewaikC1 SeE SoteieE ioiosnotty heEEDoschhiasersvheedteovfatnoonxsexasinad; ses whole blood sasple condizion Individual SE WhitEe BEloodnGsali s/iPaiatceoinoer Norghetogy Vaises: B21 platelet ciueps graded as 1 it presens ac any level) ow5 xD SBoiutspEmaettsreSoimneills ~ LR ehervad or nov exantned: 00 vote blood sample condition IndiviTHHduoEEalDDCSongheHutauaetmmionpnlveaeastmnutses: wei5r 1 DBaRrIeEnRthEee thessbootasin time -- (CompanySantized. Doesnotcontain Tscacar ww S2001y6GoSvaeoSriyTinRoityit OneGrinRepo Ess Durst INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES (Continued) avian sem 1s iam Cronos hs E E E i EE m en E AST - aspartate aminotransferase EE e i aGCCEaR GBEEHJwTCCChSmEEh TdemarsnherachasreielseieErorLdhaRtesR sseemE ninson meZsoeTaEtTsEsWaneeEcon E 35 7 E2TE SEE n ectomn of ae rn en conmninion WE [ aSp Ei mEemR-- e. Z&C Sommomlmnhboe ELIE Ww CompanySze. Does notonan 5ACot EE 2H9002-4DD5a1y6GG:oavvSaauggbceehSSvtloundyiyciiToRRnaaittcsistwvyiitthhOOnnGeeeGneernaetoionnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPpoonntt55338866 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES (Continued) 2c6e8ptPiioens CooFl3FiaHtoeripehrolCohryinVoa)l,uesa,sdWhSipteceiaBlloSoodrCear1r1ac/iopnisateier Hershotocy Yeloms (wich the 3H1I See riznoer HbiicorhospcooErpotecniveattssess(son) por nig sSovneeSnia 400 per sonsSomomumnceuss iow moderate LRiso soterate S Zteseeuscdiaia lHI im sores: eCERnariTnednisvoindeu,alo1a1niosfe)whdiactha oarree nSoetbiariepmoerdteTdr, Gt T may bLe duSe to one of the foliosing ressens or Shhaecesammsp.lehwsaustEcilcoiseertd S(afmoprlehemZoartoalnoaglyysoirsco0s0gHu)iation daca) (cLom Sousa whe sat tenn tao, - enone we wens renEasier pFeeernidooramnreddannodyniuliWdeausimisacvcheiheoTrnuvscaosprideoerndiotvUmualegudac:meiccohrFdoertshsexeaessRrEbLieei(:nrgusifJneBsSsiaLiLcnMhbaiAa cwoerrtasienmrviaaltute,aacahottesiosio0n0s vero --- `Company Saniized. Doss not contain Ts ca _ 2i Bl] mmm omamemm u mnumm gm 2 | Fl OEEERG EES | HH nEEER snnam [a far) BF | mmmmn gggngasens mmnns smgmmmsecs ~ i i jJE | mSnmdaEssEinGan m243maeiimnss i Jv) osmmunmoosumnm 1ii BENE aman I, 3 4 i srgEzasaa amines 5% i: i Ee | 0 osssersnzes osssssssnes -8gg i)T;h sessEEEEEs |: REENNNE 8 i z i a " | | | |  |: || g B| Fema moms EIR Mich che I |Bom Bhan , | : BRI GEmnEEE mmm ~. 2| z i le S33E3R%0E sanrvavar : | ddsssisasn dedeiivds ) z BOGMEEIGE mmm i |3 : ; # ! mom : Emmy ~ igonThE !| | | sessemsass Tosssessusss | ~~ 4 a2 i `| i ] 2 | EEEEEEEEEE EEEEEEELES 3 i| FH | 3 : $3] EELEEEEEEE SIRNQAIANG EEEEEEEEEE D=egusges - ii 1go;13%3] ERET 3 CE EEE mmm smnnaEnEm wma g i BE ommaEmn ames i : | S: 8|) Foassrzaessizizioasds 4| sRaizdaEgnaaasasss He : no : | 22 g5| Fessmperser serespenes | - : | - i 38 z 23 23 1, & mu j : oH Hh 3 g 8 | EEE BEEEEE EE EEEEEEEE : i BEES EEEEEE BE BEEEEEEE 4 ONE om onunm - i ] i#2H3] 393833 9N8E3E% 2O3B sosmsnmssmaems 2 | fey ommommmon mum 2 3 283% 333ARY 23 ganvanEa 3 ol i 5 IIE : i gE 2 EEEE EEEEEE : 5 EEEESEEE | i i : 2 251 sme spears ors zscsssse | -i : - 3 5 B3 El I8ERSAISIR Ne NNNNNA SrREsRESRe SANNA Se | Hl Emme sumssen B21 Hl ddesddidds 2NEIZLE=RR duffsitids 2ENENQTEAR Iie oom hh od Somme mee i | HERE EERE ;Pogr | s ARmIEnS s mnmiie To jile mmm mem i Eos ame 3 Boreas annals ly g i 83]; pEzEziee : Jinasneady = i 5 g | : ssgsassEss : ss3ssngEss no: : z 5 % sagmzenves rrezesvezs ~ Fg 25 THEE pms g g i i| 3 i S | F | | 1 | 8 - 22 33| 68Rs%3ARy seaREsEuan 2 2 B3 sn me I: i| gl I 5 | rims gaasaenans | 8 | Exnaneses ater | po Fon) Epggmmesss gmaseses =) he ; dE ommnmn anna " i | 3gl CET) | | oe ESZSIIzSiIoE|IsNsSr mmm egsIygngeeagnsIiasys ospanm #3] szzeusazes ? zeszamnane 3 ly : KH | 8 geessmezsr T sssssssssy | i| 8 | a. | 3 Sse sea ` i8 _ 3 i 5 3| `| sgeesgesss shessesens } CHI 14] wm mmm - fiu, memmm owmmess 2i 3% : TH IEEE ua gn ; |B) mmm mmmes iq ls i dBm sme | Ejsi Hen en g| ossssessuss f spsessess | i IE i | 8 {|| i | RERRENER EzEmEiEass 3| sesssssses smmssesane 5 | EESEESSAEE EhEEEERES 3 # FagIEI sms - il { g;|| I332E23E33E82 ugsmossmsssmss 3 oz HERS s223:48% 33%RNsas 3 BF] ena mmnELem 5] I eagngzases samssasese E2s 3) 8? sessnssens : sennpasas iz : : : i:g $ | | k | | | | Pa. 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Doesnotcontain TSCA CBI --- ws 9H0--24D5a1y6:GavSaugbcehSrtoundiye TinoxRiactistywith One-Generation Reproduction Evaluations DuPont5386 - Individual Hepatic Beta-Oxidation Activity In Male Rats At The 10-Day Time Point Animal Beta-Oxidation Rate Group Number (nmolimin/meg protein 1 645904 68 645905 46 645906 33 645907 61 645908 28 m 645909 71 645910 82 645911 7.5 645912 1L1 645913 106 v 645914 91 645915 123 645916 87 - 645917 82 645918 143 vit 645919 17.7 645920 17.1 645921 93 645922 174 645923 205 = `Company Sanitized. Does not contain TSCA CBI EE H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evalustions DuPont$386 = Individual Hepatic Beta-Oxidation Activity In Male Rats At The 90-Day Time Point Group 1 Animal Beta-Oxidation Rate Number __ (nmol/min/mg protein) 643241 60 643300 58 643143 29 643205 64 643235 46 mn 643173 157 643290 9.1 643272 67 643292 162 643228 172 v 643250 208 643243 209 643311 184 - 643318 209 643247 25 vit 643194 322 643252 357 643260 545 643315 516 643215 48.5 `Company Sanitized. Doesnotcontain TSCA CBI 5 H-24516: Subchronic Toxicity 0-Day Gavage Study in Rats with One-Generaton Reproduction Exaltions DuPont5386 - Individual Hepatic Beta-Oxidation Activity In Male Rats At The 36-Day Recovery Time Point Animal Beta-Oxidation Rate Group Number __(nmol/imin/me protein 1 643237 124 643226 91 643195 60 643246 0.7 643253 ss vi 643225 278 643296 28 643258 345 643316 344 643220 264 Company Sanitized. Dossnot contain Tsca cay _-- 55028D5a1y6v: aSugotSotundcy mTRoatyith One Generation Reproduction valunions Duron 386 ~~. Individual Hepatic Beta-Oxidation ActivitIyn Male Rats At The 92-Day Recovery Time Point Animal Beta-Oxidation Rate Grou Number (nmol/min/mg protein) I 643145 87 643210 10.0 643232 79 643265 8.6 643268 64 vi 643149 2s 6ca4s3i152 2715.8 643283 25.0 643295 26.7 - Gompany Sanitized. Does nol contain TSCA CB1 ---------------- eee. H9-02-4D5a1y6G:avSaugbcehrSotnuidcy TinoxRiacistywith One-Generaton Reproduction Evaluations DuPont:5386 - Individual Hepatic Beta-Oxidation Activity In Female Rats At The 10-Day Time Point Animal Beta-Oxidation Rate Group Number (nmoimin/mg protein) I 645926 66 645927 722 645928 77 645929 70 645930 120 v 645931 99 645932 86 645933 47 645934 60 645935 9.4 vi 645936 136 645937 134 645938 19 - 645939 178 645940 123 vii 645941 187 645942 218 645943 209 645944 18.7 645945 254 - `Company Sanitized. Doesnotcontain TSCA CBI Tw 124516: Subehronic 50-Day Gavage Study TinoxRiactistywith One. Generation Reproducion Evaluations DuPont5386 ~ Individual Hepatic Beta-Oxidation Activity In Female Rats At The 90-Day Time Point Animal Beta-Oxidation Rate Group Number __(amolimin/mg protein 1 643477 s1 643374 71 643406 94 643486 71 643361 99 Vv 643390 74 643396 123 643380 9.0 643433 172 643389 155 vi 643322 293 643489 252 643409 322 - 643366 244 643367 23 vin 643341 303 643370 25 643446 304 643435 29 643466 214 - Company Sanitized. Does not contain TSCA CBI _ 5H02.4D5a1y6:GavSaugbeehSrtoundiyc iTnoxRiactistywith OnGeeneration Reprdsetion Elution DuPont5386 --- Individual Hepatic Beta-Oxidation Activity In Female Rats At The 36-Day Recovery Time Point Group un vi Animal Number 643405 643425 643448 643426 643415 643347 643456 664433344253 645551 Beta-Oxidation Rate (nmol/min/mg protein) 10.5 11s 95 84 83 189 148 2201.12 26 Company Sanitized. Doss not contain TSCA CBI = --_-- 9H-02-4D5a1y6:GavSaugbcehSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont5386 - Individual Hepatic Beta-Oxidation Activity In Female Rats At The 92-Day Recovery Time Point Animal Beta-Oxidation Rate Group Number __(nmol/min/mg protein) 1 643383 192 643384 152 643402 190 643465 193 643484 194 vin 643329 359 643365 343 643388 279 643450 312 643487 2.1 - Company Sanitized. Does not contain TSCA CBI =--------:-------G-------- H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One Generation Reproduction Evaluations DuPont-5386 APPENDIX M INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS >ompany Sanitized. 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